Literature summary for 1.6.5.2 extracted from

Guo, W.; Reigan, P.; Siegel, D.; Zirrolli, J.; Gustafson, D.; Ross, D.
Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition (2005), Cancer Res., 65, 10006-10015.

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Inhibitors

Inhibitors	Comment	Organism	Structure
ES936	i.e. 5-methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, suicide inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant enzyme	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MDA-468 cell	human breast cancer cell line lacking enzyme due to genetic polymorphism	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD(P)H + H+ + 17-allylamino-demethoxygeldanamycin	-	Homo sapiens	NAD(P)+ + reduced 17-allylamino-demethoxygeldanamycin	product exhibits superior Hsp90 inhibition and is involved in Hsp70 induction and Raf-1 degradation	?

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Release 2023.1 (January 2023)