General Stability | Organism |
---|---|
stable to dialysis against 0.01 M potassium phosphate buffer, pH 7.5 and 0.01 M Tris buffer, pH 8.2 and 8.9, 16 h or more at 3°C | Canis lupus familiaris |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | 1 mM, 50% inhibition | Canis lupus familiaris | |
2,4-Dinitroaniline | 0.1 mM, 33% inhibition | Canis lupus familiaris | |
2,4-Dinitronaphthol | 0.1 mM, 90% inhibition | Canis lupus familiaris | |
2,4-dinitrophenol | 0.1 mM, 39% inhibition | Canis lupus familiaris | |
3,3'-methylene-bis(4-hydroxycoumarin) | 0.1 mM, 97% inhibition | Canis lupus familiaris | |
8-hydroxyquinoline | 1 mM, 50% inhibition | Canis lupus familiaris | |
alpha,alpha'-dipyridyl | IC50: 1 mM | Canis lupus familiaris | |
ethyl bis(2-hydroxy-4-oxo-4H-chromen-3-yl)acetate | trivial tromexan, 0.1 mM, 79% inhibition | Canis lupus familiaris | |
Phenindione | 0.1 mM, 92% inhibition | Canis lupus familiaris | |
salicylate | 1 mM, 62% inhibition | Canis lupus familiaris | |
warfarin | 1 mM, 70% inhibition | Canis lupus familiaris |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Canis lupus familiaris | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Canis lupus familiaris |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Canis lupus familiaris | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.9 | - |
- |
Canis lupus familiaris |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-methyl-1,4-naphthoquinone + NAD(P)H | artificial acceptor, trivial name menadione | Canis lupus familiaris | 2-methyl-1,4-naphthoquinol + NAD(P)+ | - |
? | |
2-methyl-3-phytyl-1,4-naphthoquinone + NAD(P)H | trivial name vitamin K1 | Canis lupus familiaris | 2-methyl-3-phytyl-1,4-naphthohydroquinone + NAD(P)+ | - |
? | |
2-methyl-3-phytyl-1,4-naphthoquinone + NAD(P)H | no activity with vitamin K1 diphosphate, menadione diphosphate, vitamin K1 oxide, d-alpha-tocopherol and d-alpha-tocoquinone | Canis lupus familiaris | 2-methyl-3-phytyl-1,4-naphthohydroquinone + NAD(P)+ | - |
? | |
benzoquinone + 2 NAD(P)H + H+ | - |
Canis lupus familiaris | benzohydroquinone + 2 NAD(P)+ | - |
? | |
coenzyme Q10 + NAD(P)H | - |
Canis lupus familiaris | reduced coenzyme Q10 + NAD(P)+ | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
- |
- |
some days | Canis lupus familiaris |
20 | - |
several h | Canis lupus familiaris |
57 | - |
5 min, 90% loss of activity | Canis lupus familiaris |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.7 | - |
decrease above | Canis lupus familiaris |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
deamino-NADH | - |
Canis lupus familiaris | |
FAD | stimulates | Canis lupus familiaris | |
FMN | stimulation | Canis lupus familiaris | |
NADH | - |
Canis lupus familiaris | |
NADPH | - |
Canis lupus familiaris |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
1 | - |
IC50: 1 mM | Canis lupus familiaris | alpha,alpha'-dipyridyl |