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Literature summary for 1.6.5.10 extracted from

  • Hong, Y.; Wang, G.; Maier, R.J.
    The NADPH quinone reductase MdaB confers oxidative stress resistance to Helicobacter hepaticus (2008), Microb. Pathog., 44, 169-174.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Helicobacter hepaticus
-
strain ATCC51449
-
Helicobacter hepaticus ATCC 51449
-
strain ATCC51449
-

Purification (Commentary)

Purification (Comment) Organism
-
Helicobacter hepaticus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,4-naphthoquinone + NADPH + H+ two-electron transfer mechanism from NADPH to quinone Helicobacter hepaticus 1,4-naphthoquinol + NADP+
-
?
2 ferricyanide + NADPH
-
Helicobacter hepaticus 2 ferrocyanide + NADP+ + H+
-
?
menadione + NADPH + H+ two-electron transfer mechanism from NADPH to quinone Helicobacter hepaticus ? + NADP+
-
?
oxidized dichlorophenolindophenol + NADPH + H+
-
Helicobacter hepaticus reduced dicholorophenolindophenol + NADP+
-
?
ubiquinone-0 + NADPH + H+ two-electron transfer mechanism from NADPH to quinone Helicobacter hepaticus ubiquinol-0 + NADP+
-
?
ubiquinone-1 + NADPH + H+ two-electron transfer mechanism from NADPH to quinone Helicobacter hepaticus ubiquinol-1 + NADP+
-
?

Subunits

Subunits Comment Organism
? x * 21000-22000, SDS-PAGE Helicobacter hepaticus

Synonyms

Synonyms Comment Organism
MdaB
-
Helicobacter hepaticus
NADPH quinone reductase
-
Helicobacter hepaticus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Helicobacter hepaticus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Helicobacter hepaticus

Cofactor

Cofactor Comment Organism Structure
flavin flavoprotein, adsorption spectrum with a major peak at 456 nm Helicobacter hepaticus
NADPH NADH could also be used as an electron donor to MdaB but with much lower efficiency, about 3% of those with NADPH Helicobacter hepaticus