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Literature summary for 1.6.3.5 extracted from

  • Kolodecik, T.R.; Reed, A.M.; Date, K.; Shugrue, C.A.; Patel, V.; Chung, S.L.; Desir, G.V.; Gorelick, F.S.
    The serum protein renalase reduces injury in experimental pancreatitis (2017), J. Biol. Chem., 292, 21047-21059 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q5VYX0
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Mus musculus A7RDN6
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General Information

General Information Comment Organism
physiological function genetic deletion of renalase results in more severe disease in murine models of acute pancreatitis, and administering recombinant RNLS to cerulein-exposed wild-type mice after pancreatitis onset is protective. Plasma membrane calcium ATPase 4b is expressed in both murine and human acinar cells and a PMCA4b-selective inhibitor worsens pancreatitis-induced injury and blocks the protective effects of rcombinant RNLS Mus musculus
physiological function in isolated pancreatic lobules, pretreatment with recombinant human renalase blocks zymogen activation caused by cerulein, carbachol, and a bile acid. Renalase also blocks cerulein-induced cell injury and histological changes. Genetic deletion of renalase results in more severe disease in murine models of acute pancreatitis, and administering recombinant human RNLS to cerulein-exposed wild-type mice after pancreatitis onset is protective Homo sapiens