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Literature summary for 1.6.3.1 extracted from

  • Gao, L.; Mann, G.E.
    Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling (2009), Cardiovasc. Res., 82, 9-20.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
angiotensin II potent stimulator of NAD(P)H oxidase O2- production in the vasculature Mus musculus
angiotensin II potent stimulator of NAD(P)H oxidase O2- production in the vasculature Homo sapiens
angiotensin II potent stimulator of NAD(P)H oxidase O2- production in the vasculature Rattus norvegicus
angiotensin II potent stimulator of NAD(P)H oxidase O2- production in the vasculature Bos taurus

Application

Application Comment Organism
medicine as NAD(P)H oxidase activation may have dual actions in diabetes, selective targeting of the deleterious effects of sustained NAD(P)H oxidase activation, such as eNOS uncoupling, mitochondrial dysfunction, and impaired antioxidant gene expression, may prove beneficial in the treatment of diabetes Mus musculus
medicine as NAD(P)H oxidase activation may have dual actions in diabetes, selective targeting of the deleterious effects of sustained NAD(P)H oxidase activation, such as eNOS uncoupling, mitochondrial dysfunction, and impaired antioxidant gene expression, may prove beneficial in the treatment of diabetes Homo sapiens
medicine as NAD(P)H oxidase activation may have dual actions in diabetes, selective targeting of the deleterious effects of sustained NAD(P)H oxidase activation, such as eNOS uncoupling, mitochondrial dysfunction, and impaired antioxidant gene expression, may prove beneficial in the treatment of diabetes Rattus norvegicus
medicine as NAD(P)H oxidase activation may have dual actions in diabetes, selective targeting of the deleterious effects of sustained NAD(P)H oxidase activation, such as eNOS uncoupling, mitochondrial dysfunction, and impaired antioxidant gene expression, may prove beneficial in the treatment of diabetes Bos taurus

Protein Variants

Protein Variants Comment Organism
additional information a C242T mutation in the p22phox gene is associated with insulin resistance in non-diabetic subjects Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
diphenylene iodonium
-
Bos taurus
diphenylene iodonium
-
Homo sapiens
diphenylene iodonium
-
Mus musculus
diphenylene iodonium
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-
membrane
-
Homo sapiens 16020
-
membrane
-
Rattus norvegicus 16020
-
membrane
-
Bos taurus 16020
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aortic endothelial cell
-
Bos taurus
-
aortic smooth muscle cell
-
Mus musculus
-
aortic smooth muscle cell
-
Homo sapiens
-
aortic smooth muscle cell
-
Rattus norvegicus
-
aortic smooth muscle cell
-
Bos taurus
-
bone
-
Mus musculus
-
bone
-
Homo sapiens
-
bone
-
Rattus norvegicus
-
bone
-
Bos taurus
-
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain
-
Bos taurus
-
breast
-
Mus musculus
-
breast
-
Homo sapiens
-
breast
-
Rattus norvegicus
-
breast
-
Bos taurus
-
colon
-
Mus musculus
-
colon
-
Homo sapiens
-
colon
-
Rattus norvegicus
-
colon
-
Bos taurus
-
coronary artery endothelial cell
-
Rattus norvegicus
-
coronary artery endothelial cell
-
Bos taurus
-
endothelial cell
-
Mus musculus
-
endothelium
-
Mus musculus
-
endothelium
-
Homo sapiens
-
endothelium
-
Rattus norvegicus
-
endothelium
-
Bos taurus
-
eye
-
Mus musculus
-
eye
-
Homo sapiens
-
eye
-
Rattus norvegicus
-
eye
-
Bos taurus
-
gastrointestinal tract
-
Mus musculus
-
gastrointestinal tract
-
Homo sapiens
-
gastrointestinal tract
-
Rattus norvegicus
-
gastrointestinal tract
-
Bos taurus
-
heart
-
Mus musculus
-
heart
-
Homo sapiens
-
heart
-
Rattus norvegicus
-
heart
-
Bos taurus
-
HUVEC cell
-
Homo sapiens
-
inner ear
-
Mus musculus
-
inner ear
-
Homo sapiens
-
inner ear
-
Rattus norvegicus
-
inner ear
-
Bos taurus
-
kidney Nox4 is the predominant isoform expressed in renal cells Mus musculus
-
kidney Nox4 is the predominant isoform expressed in renal cells Homo sapiens
-
kidney Nox4 is the predominant isoform expressed in renal cells Rattus norvegicus
-
kidney Nox4 is the predominant isoform expressed in renal cells Bos taurus
-
lung
-
Mus musculus
-
lung
-
Homo sapiens
-
lung
-
Rattus norvegicus
-
lung
-
Bos taurus
-
lymphoid tissue
-
Mus musculus
-
lymphoid tissue
-
Homo sapiens
-
lymphoid tissue
-
Rattus norvegicus
-
lymphoid tissue
-
Bos taurus
-
microvessel
-
Mus musculus
-
ovary
-
Mus musculus
-
ovary
-
Homo sapiens
-
ovary
-
Rattus norvegicus
-
ovary
-
Bos taurus
-
phagocyte
-
Mus musculus
-
phagocyte
-
Homo sapiens
-
phagocyte
-
Rattus norvegicus
-
phagocyte
-
Bos taurus
-
placenta
-
Mus musculus
-
placenta
-
Homo sapiens
-
placenta
-
Rattus norvegicus
-
placenta
-
Bos taurus
-
prostate gland
-
Mus musculus
-
prostate gland
-
Homo sapiens
-
prostate gland
-
Rattus norvegicus
-
prostate gland
-
Bos taurus
-
retina
-
Mus musculus
-
retina
-
Homo sapiens
-
retina
-
Rattus norvegicus
-
retina
-
Bos taurus
-
salivary gland
-
Mus musculus
-
salivary gland
-
Homo sapiens
-
salivary gland
-
Rattus norvegicus
-
salivary gland
-
Bos taurus
-
skeletal muscle
-
Mus musculus
-
skeletal muscle
-
Homo sapiens
-
skeletal muscle
-
Rattus norvegicus
-
skeletal muscle
-
Bos taurus
-
spleen
-
Mus musculus
-
spleen
-
Homo sapiens
-
spleen
-
Rattus norvegicus
-
spleen
-
Bos taurus
-
testis
-
Mus musculus
-
testis
-
Homo sapiens
-
testis
-
Rattus norvegicus
-
testis
-
Bos taurus
-
thyroid
-
Mus musculus
-
thyroid
-
Homo sapiens
-
thyroid
-
Rattus norvegicus
-
thyroid
-
Bos taurus
-
uterus
-
Mus musculus
-
uterus
-
Homo sapiens
-
uterus
-
Rattus norvegicus
-
uterus
-
Bos taurus
-
vasculature
-
Mus musculus
-
vasculature
-
Homo sapiens
-
vasculature
-
Rattus norvegicus
-
vasculature
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + H+ + O2
-
Mus musculus NAD+ + H2O2
-
?
NADH + H+ + O2
-
Homo sapiens NAD+ + H2O2
-
?
NADH + H+ + O2
-
Rattus norvegicus NAD+ + H2O2
-
?
NADH + H+ + O2
-
Bos taurus NAD+ + H2O2
-
?
NADPH + H+ + O2
-
Mus musculus NADP+ + H2O2
-
?
NADPH + H+ + O2
-
Homo sapiens NADP+ + H2O2
-
?
NADPH + H+ + O2
-
Rattus norvegicus NADP+ + H2O2
-
?
NADPH + H+ + O2
-
Bos taurus NADP+ + H2O2
-
?

Synonyms

Synonyms Comment Organism
Duox1 isoform Mus musculus
Duox1 isoform Homo sapiens
Duox1 isoform Rattus norvegicus
Duox1 isoform Bos taurus
Duox2 isoform Mus musculus
Duox2 isoform Homo sapiens
Duox2 isoform Rattus norvegicus
Duox2 isoform Bos taurus
NADPH oxidase
-
Mus musculus
NADPH oxidase
-
Homo sapiens
NADPH oxidase
-
Rattus norvegicus
NADPH oxidase
-
Bos taurus
NOX1 isoform Mus musculus
NOX1 isoform Homo sapiens
NOX1 isoform Rattus norvegicus
NOX1 isoform Bos taurus
Nox2 isoform Mus musculus
Nox2 isoform Homo sapiens
Nox2 isoform Rattus norvegicus
Nox2 isoform Bos taurus
NOX3 isoform Mus musculus
NOX3 isoform Homo sapiens
NOX3 isoform Rattus norvegicus
NOX3 isoform Bos taurus
Nox4 isoform Mus musculus
Nox4 isoform Homo sapiens
Nox4 isoform Rattus norvegicus
Nox4 isoform Bos taurus
NOX5 isoform Mus musculus
NOX5 isoform Homo sapiens
NOX5 isoform Rattus norvegicus
NOX5 isoform Bos taurus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Mus musculus
FAD
-
Homo sapiens
FAD
-
Rattus norvegicus
FAD
-
Bos taurus
heme
-
Mus musculus
heme
-
Homo sapiens
heme
-
Rattus norvegicus
heme
-
Bos taurus

Expression

Organism Comment Expression
Rattus norvegicus adiponectin suppresses NADPH oxidase expression/activity down
Homo sapiens leptin suppresses NADPH oxidase expression/activity down
Bos taurus fatty acids activate NADPH oxidase expression/activity up
Rattus norvegicus tumor necrosis factor-alpha activates NADPH oxidase expression/activity. NAD(P)H oxidase is increased in the retina of diabetic rats up

General Information

General Information Comment Organism
physiological function NAD(P)H oxidase is the major source of reactive oxygen species generation in the vasculature in response to high glucose and advanced glycation end-products. NAD(P)H oxidase in phagocytic cells releases reactive oxygen species as a defense against pathogens. Activation of NAD(P)H oxidase in diabetes leads to a cascade of reactive oxygen species production and impaired antioxidant defenses. In early stages of diabetes, NAD(P)H oxidase-derived reactive oxygen species may serve as intracellular mediators to regulate redox-sensitive transcription factors (e.g. Nrf2) involved in adaptive responses to oxidative stress Mus musculus
physiological function NAD(P)H oxidase is the major source of reactive oxygen species generation in the vasculature in response to high glucose and advanced glycation end-products. NAD(P)H oxidase in phagocytic cells releases reactive oxygen species as a defense against pathogens. Activation of NAD(P)H oxidase in diabetes leads to a cascade of reactive oxygen species production and impaired antioxidant defenses. In early stages of diabetes, NAD(P)H oxidase-derived reactive oxygen species may serve as intracellular mediators to regulate redox-sensitive transcription factors (e.g. Nrf2) involved in adaptive responses to oxidative stress Homo sapiens
physiological function NAD(P)H oxidase is the major source of reactive oxygen species generation in the vasculature in response to high glucose and advanced glycation end-products. NAD(P)H oxidase in phagocytic cells releases reactive oxygen species as a defense against pathogens. Activation of NAD(P)H oxidase in diabetes leads to a cascade of reactive oxygen species production and impaired antioxidant defenses. In early stages of diabetes, NAD(P)H oxidase-derived reactive oxygen species may serve as intracellular mediators to regulate redox-sensitive transcription factors (e.g. Nrf2) involved in adaptive responses to oxidative stress Rattus norvegicus
physiological function NAD(P)H oxidase is the major source of reactive oxygen species generation in the vasculature in response to high glucose and advanced glycation end-products. NAD(P)H oxidase in phagocytic cells releases reactive oxygen species as a defense against pathogens. Activation of NAD(P)H oxidase in diabetes leads to a cascade of reactive oxygen species production and impaired antioxidant defenses. In early stages of diabetes, NAD(P)H oxidase-derived reactive oxygen species may serve as intracellular mediators to regulate redox-sensitive transcription factors (e.g. Nrf2) involved in adaptive responses to oxidative stress Bos taurus