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Literature summary for 1.6.3.1 extracted from

  • El-Benna, J.; Dang, P.M.; Perianin, A.
    Peptide-based inhibitors of the phagocyte NADPH oxidase (2010), Biochem. Pharmacol., 80, 778-785.
    View publication on PubMed
Search for more literature for 1.6.3.1

Activating Compound

Activating Compound Comment Organism Structure
additional information NADPH oxidase can be activated in a cell-free system by mixing cytosol and plasma membranes isolated from resting neutrophils or macrophages in the presence of Mg2+, GTP and an anionic amphiphile such as arachidonic acid or sodium dodecyl sulfate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-(2-amino-ethyl)-benzolsulphonyl-fluoride
-
 Homo sapiens
4-(2-amino-ethyl)-benzolsulphonyl-fluoride
-
 Rattus norvegicus
4-(2-aminoethyl)-benzenesulfonyl fluoride
-
 Homo sapiens
apocynin poor inhibitor of NADPH oxidase Homo sapiens
apocynin
-
 Rattus norvegicus
AYRRNSVRFL inhibits NADPH oxidase activation Homo sapiens
diphenylene iodonium
-
 Homo sapiens
diphenylene iodonium
-
 Rattus norvegicus
FAVHHDEEKDVITG
-
 Homo sapiens
FLRGSSACCSTRVRRQL
-
 Homo sapiens
additional information trimer hydroxylated quinone is the major active compound in AOP-1, with strong inhibitory activity against vascular endothelial cell NADPH oxidase with an IC50 of 0.000031 mM at 22°C, pH not specified in the publication Homo sapiens
additional information trimer hydroxylated quinone is the major active compound in AOP-1, with strong inhibitory activity against vascular endothelial cell NADPH oxidase with an IC50 of 0.000031 mM at 22°C, pH not specified in the publication Rattus norvegicus
Phenylarsine oxide
-
 Homo sapiens
RGVHFIF
-
 Homo sapiens
RSRKRLSQDAYRRNSVRF inhibits NADPH oxidase activation Homo sapiens
SNSESGPRGVHFIFNKEN
-
 Homo sapiens
VAS3947 i.e. 3-benzyl-7-(2-oxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine, specific low micromolar NADPH oxidase inhibitor Homo sapiens
VAS3947 i.e. 3-benzyl-7-(2-oxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine, specific low micromolar NADPH oxidase inhibitor Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
cytosol NOX components are distributed between the cytosol (p47phox, p67phox, p40phox and Rac1/2) and the plasma membrane and membranes of specific granules Homo sapiens 5829
-
membrane
-
 Homo sapiens 16020
-
membrane NOX components are distributed between the cytosol (p47phox, p67phox, p40phox and Rac1/2) and the plasma membrane and membranes of specific granules Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A7r5 cell
-
 Rattus norvegicus
-
aorta
-
 Rattus norvegicus
-
Caco-2 cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
HUVEC cell
-
 Homo sapiens
-
phagocyte
-
 Homo sapiens
-
umbilical vein
-
 Homo sapiens
-
vascular endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
-
 Homo sapiens NADP+ + H2O2
-
 ?
NADPH + H+ + O2
-
 Rattus norvegicus NADP+ + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
NADPH oxidase
-
 Homo sapiens
NADPH oxidase
-
 Rattus norvegicus
NADPH oxidase the phagocyte NADPH oxidase is a multicomponent enzyme complex comprising six proteins, namely p22phox (phox: phagocyte oxidase), gp91phox, p47phox, p67phox, p40phox and the small G-protein Rac1 or Rac2 Homo sapiens
NOX
-
 Homo sapiens
NOX
-
 Rattus norvegicus
NOX1 isozyme Homo sapiens
Nox2 isozyme Homo sapiens
Nox4 isozyme Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
FAD
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function NADPH oxidase is a major source of reactive oxygen species in aortas of spontaneously hypertensive rats Rattus norvegicus