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Literature summary for 1.6.3.1 extracted from

  • Piwkowska, A.; Rogacka, D.; Jankowski, M.; Dominiczak, M.H.; Stepi?ski, J.K.; Angielski, S.
    Metformin induces suppression of NAD(P)H oxidase activity in podocytes (2010), Biochem. Biophys. Res. Commun., 393, 268-273.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
apocynin
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
podocyte
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + H+ + O2
-
Mus musculus NAD+ + H2O2
-
?

Cofactor

Cofactor Comment Organism Structure
FAD
-
Mus musculus
heme
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus 2 mM metformin induces suppression of NAD(P)H oxidase activity by 45% in high glucose (30 mM) and by 60% in normal glucose concentrations (5.6 mM) down
Mus musculus high glucose concentration (30 mM) increases NAD(P)H oxidase activity by about 27% up

General Information

General Information Comment Organism
physiological function NAD(P)H oxidase is the main source of reactive oxygen species in diabetic podocytes and their production contributes to the development of diabetic nephropathy Mus musculus