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Literature summary for 1.6.3.1 extracted from

  • Usatyuk, P.V.; Romer, L.H.; He, D.; Parinandi, N.L.; Kleinberg, M.E.; Zhan, S.; Jacobson, J.R.; Dudek, S.M.; Pendyala, S.; Garcia, J.G.; Natarajan, V.
    Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin (2007), J. Biol. Chem., 282, 23284-23295.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cytochalasin D enhancement of basal and hyperoxia-induced reactive oxygen species formation Homo sapiens
latrunculin A enhancement of basal and hyperoxia-induced reactive oxygen species formation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
phallacidin pretreatment of human pulmonary artery endothelial cells before induction of hyperoxia attenuates hyperoxia-induced cortical actin thickening and reactive oxygen species production Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
artery human pulmonary artery endothelial cell, induction of NAD(P)H oxidase by exposure to hyperoxia for 3 h. Pretreatment of cells with the actin-stabilizing agent phallacidin attenuates hyperoxia-induced cortical actin thickening and reactive oxygen species production, whereas cytochalasin D and latrunculin A enhance basal and hyperoxia-induced reactive oxygen species formation. A 3-h hyperoxic exposure enhances the tyrosine phosphorylation of cortactin and interaction between cortactin and subunit p47phox. Transfection of cells with cortactin small interfering RNA or myristoylated cortactin Src homology domain 3 blocking peptide attenuated reactive oxygen species production and the hyperoxia-induced translocation of p47phox to the cell periphery Homo sapiens
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endothelium lung endothelial cell Homo sapiens
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lung lung endothelial cell Homo sapiens
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