Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cytochalasin D | enhancement of basal and hyperoxia-induced reactive oxygen species formation | Homo sapiens | |
latrunculin A | enhancement of basal and hyperoxia-induced reactive oxygen species formation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phallacidin | pretreatment of human pulmonary artery endothelial cells before induction of hyperoxia attenuates hyperoxia-induced cortical actin thickening and reactive oxygen species production | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
artery | human pulmonary artery endothelial cell, induction of NAD(P)H oxidase by exposure to hyperoxia for 3 h. Pretreatment of cells with the actin-stabilizing agent phallacidin attenuates hyperoxia-induced cortical actin thickening and reactive oxygen species production, whereas cytochalasin D and latrunculin A enhance basal and hyperoxia-induced reactive oxygen species formation. A 3-h hyperoxic exposure enhances the tyrosine phosphorylation of cortactin and interaction between cortactin and subunit p47phox. Transfection of cells with cortactin small interfering RNA or myristoylated cortactin Src homology domain 3 blocking peptide attenuated reactive oxygen species production and the hyperoxia-induced translocation of p47phox to the cell periphery | Homo sapiens | - |
endothelium | lung endothelial cell | Homo sapiens | - |
lung | lung endothelial cell | Homo sapiens | - |