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Literature summary for 1.6.3.1 extracted from

  • Stokes, K.Y.; Russell, J.M.; Jennings, M.H.; Alexander, J.S.; Granger, D.N.
    Platelet-associated NAD(P)H oxidase contributes to the thrombogenic phenotype induced by hypercholesterolemia (2007), Free Radic. Biol. Med., 43, 22-30.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine platelets and leukocytes from high cholesterol-fed mice exhibit elevated generation of reactive oxygen species compared to normal diet mice. Hypercholesterolemia-induced leukocyte recruitment is attenuated in Cu,Zn-superoxide dismutase transgenic, and NAD(P)H oxidase-knockout mice on high cholesterol diet. Platelets from NAD(P)H oxidase-knockout mice on high cholesterol diet exhibit low levels of adhesion comparable to those of wild-type on normal diet. Overexpression of Cu,Zn-superoxide dismutase or, to a lesser extent, NAD(P)H oxidase subunit gp91 deficiency restores arteriolar vasorelaxation responses toward normal diet wild-type levels Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol expression of cytosolic subunits of NAD(P)H oxidase p47phox and p67phox is not altered by hypercholesterolemia Mus musculus 5829
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Organism

Organism UniProt Comment Textmining
Mus musculus
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wild-type, Cu,Zn-superoxide dismutase transgenic, and NAD(P)H oxidase-knockout mice placed on a normal or high cholesterol diet
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Source Tissue

Source Tissue Comment Organism Textmining
blood platelet expression of cytosolic subunits of NAD(P)H oxidase p47phox and p67phox is not altered by hypercholesterolemia, however, platelets and leukocytes from high cholesterol-fed mice exhibit elevated generation of reactive oxygen species compared to normal diet mice Mus musculus
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leukocyte platelets and leukocytes from high cholesterol-fed mice exhibit elevated generation of reactive oxygen species compared to normal diet mice. Hypercholesterolemia-induced leukocyte recruitment is attenuated in Cu,Zn-superoxide dismutase transgenic, and NAD(P)H oxidase-knockout mice on high cholesterol diet. Platelets from NAD(P)H oxidase-knockout mice on high cholesterol diet exhibit low levels of adhesion comparable to those of wild-type on normal diet. Overexpression of Cu,Zn-superoxide dismutase or, to a lesser extent, NAD(P)H oxidase subunit gp91 deficiency restores arteriolar vasorelaxation responses toward normal diet wild-type levels Mus musculus
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