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Literature summary for 1.6.3.1 extracted from
- Endothelin-1 inhibits NADPH oxidase activity in human abdominal aortic endothelial cells: A novel function of ETB1 receptors (2008), Endocrinology, 149, 4979-4987.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| endothelin-1 | inhibits NADPH oxidase activity, superoxide generation, and cell proliferation in human abdominal aortic endothelial cells via the ETB1-Pyk2-Rac1-Nox1 pathway. Endothelin-1 significantly attenuates NADPH oxidase activity and cell proliferation, which can be abolished by silencing of the Nox1 gene. RNA interference silencing of ETB1 receptors significantly increases NADPH oxidase activity, and blocks the inhibitory effect of endothelin-1 on NADPH oxidase activity. Endothelin-1 also attenuates angiotensin II-induced activation of NADPH oxidase and cell proliferation | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| aorta | abdominal aortic endothelial cells | Homo sapiens | - |
| endothelium | abdominal aortic endothelial cells | Homo sapiens | - |
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Release 2023.1 (January 2023)
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