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Literature summary for 1.6.3.1 extracted from

  • Owayed, A.; Dhaunsi, G.S.; Al-Mukhaizeem, F.
    Nitric oxide-mediated activation of NADPH oxidase by salbutamol during acute asthma in children (2008), Cell Biochem. Funct., 26, 603-608.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
salbutamol salbutamol treatment enhances superoxide anion production in asthma patients through nitric oxide-mediated mechanisms. It exerts beneficial antioxidant effects through activation of catalase and attenuation of lipid peroxidation Homo sapiens

Application

Application Comment Organism
medicine in peripheral blood lymphocytes from children with acute asthma, activity of NAD(P)H oxidase is significantly increased. Plasma levels of malondialdehyde, and nitric oxide are also markedly elevated, while catalase activity is decreased. Treatment of lymphocytes with salbutamol at 10 microg per ml, prevents the attenuation of catalase activity but significantly increases the levels of nitroc oxide and NAD(P)H oxidase activity. Levels of isoform NOX-1 mRNA are significantly increased in peripheral blodd lymphocytes following treatment with NO donor, S-nitroso-N-acetyl penicillamine. Subunit gp91phox protein is also two- to threefold increased following treatment with S-nitroso-N-acetyl penicillamine and leads to increased NAD(P)H oxidase activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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children with acute asthma
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Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte peripheral blood lymphocyte Homo sapiens
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