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Literature summary for 1.6.3.1 extracted from
- Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism (2007), Biochem. J., 405, 251-259.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| transforming growth factor-beta | up-regulates isoform nox4 and increases the levels of Rac1 protein, a known regulator of both isoforms Nox1 and Nox2, in a transforming growth factor-beta receptor I-dependent manner and mediates activation of the nuclear factor-kappaB pathway. The inhibitors diphenyleneiodonium and apocynin, and SB431542, an inhibitor of the transforming growth factor-beta receptor I, block up-regulation of epidermal growth factor receptor ligands and Akt activation | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| apocynin | blocks up-regulation of epidermal growth factor receptor ligands and Akt activation by transforming growth factor-beta | Rattus norvegicus |  |
| diphenyleneiodonium | blocks up-regulation of epidermal growth factor receptor ligands and Akt activation by transforming growth factor-beta | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatocyte | fetal hepatocyte | Rattus norvegicus | - |
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