Literature summary for 1.6.3.1 extracted from

Wolfort, R.M.; Stokes, K.Y.; Granger, D.N.
CD4+ T lymphocytes mediate hypercholesterolemia-induced endothelial dysfunction via a NAD(P)H oxidase-dependent mechanism (2008), Am. J. Physiol. Heart Circ. Physiol., 294, H2619-H2626.

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Application

Application	Comment	Organism
medicine	wild-type mice fed with high-cholesterol diet exhibit impaired endothelium-dependent vasodilation, enhanced superoxide generation, and increased expression of NAD(P)H oxidase subunit Nox-2 mRNA. In severe combined immunodeficient mice, in mice genetically deficient for interferon IFN-gamma, and CD4+ T-lymphocyte-deficient mice, the impaired endothelium-dependent vasodilation and enhanced superoxide generation are significantly blunted. Effects are similar in high-cholesterol fed mice genetically deficient in NAD(P)H oxidase subunit Nox-2	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	high-cholesterol fed mice genetically deficient in NAD(P)H oxidase subunit Nox-2 show an attenuation in impaired endothelium-dependent vasodilation and enhanced superoxide generation compaired to wild-type	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	fed with normal or cholesterol-enriched diet	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aorta	aortic ring	Mus musculus	-

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Release 2023.1 (January 2023)