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Literature summary for 1.6.3.1 extracted from

  • Cheranov, S.Y.; Jaggar, J.H.
    TNF-alpha dilates cerebral arteries via NAD(P)H oxidase-dependent Ca2+ spark activation (2006), Am. J. Physiol., 290, C964-C971.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
TNF-alpha activation of enzyme, resulting in an increase in intracellular H2O2 that stimulates Ca2+ sparks and transient Kca currents, leading to a reduction in global concentration of Ca2+ and vasodilation Rattus norvegicus

Application

Application Comment Organism
medicine TNF-alpha activates enzyme, resulting in an increase in intracellular H2O2 that stimulates Ca2+ sparks and transient Kca currents, leading to a reduction in global concentration of Ca2+ and vasodilation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
smooth muscle
-
 Rattus norvegicus
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