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Literature summary for 1.6.3.1 extracted from

  • Caillou, B.; Dupuy, C.; Lacroix, L.; Nocera, M.; Talbot, M.; Ohayon, R.; Deme, D.; Bidart, J.M.; Schlumberger, M.; Virion, A.
    Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues (2001), J. Clin. Endocrinol. Metab., 86, 3351-3358.
    View publication on PubMed
Search for more literature for 1.6.3.1

Localization

Localization Comment Organism GeneOntology No. Textmining
apical plasma membrane
-
 Homo sapiens 16324
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ regulates enzyme activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
164000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD(P)H + H+ + O2 Homo sapiens production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 Homo sapiens involved in Grave's disease NAD(P)+ + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NRD8
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
additional information different tissues screened for ThOX2, except for a weak signal in trachea ThOX2 in exclusively found in thyroid cells Homo sapiens
-
thyroid gland
-
 Homo sapiens
-
trachea very weak signal Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD(P)H + H+ + O2
-
 Homo sapiens NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Homo sapiens NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 involved in Grave's disease Homo sapiens NAD(P)+ + H2O2
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD flavoprotein Homo sapiens