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Literature summary for 1.6.2.4 extracted from
- Cytochrome P450 reductase: a harbinger of diffusible reduced oxygen species (2010), PLoS ONE, 5, e13272.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CPR | - |
Homo sapiens |
| cytochrome P450 reductase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 29 | 37 | assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.1 | 7.4 | assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | a diflavoenzyme | Homo sapiens |  |
| FMN | a diflavoenzyme | Homo sapiens | |
| NADPH | preferred over NADH | Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is capable of activating molecular oxygen on its own merit, generating diffusible reduced oxygen species. It deplete peroxide via diffusible radical mediated process, thereby leading to the formation of water (but without significant evolution of oxygen). CPR mediated processes are bound to be energetically wasteful and potentially hazardous owing to the unavoidable nature of the CPR to generate and deplete diffusible reduced oxygen species. Molecular mechanisms of oxygen activation and peroxide depletion by CPR, overview | Homo sapiens |
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