Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | in contrast to the inhibitory effects of 2-chloroethyl ethyl sulfide on redox cycling b cytochrome P450 reductase, spontaneous hydrogen peroxide production by the enzyme is stimulated by 2-chloroethyl ethyl sulfide. This response is concentration-dependent in the range of 0.1-10 mM, reaching a maximum at 0.3 mM | Mus musculus | |
additional information | in contrast to the inhibitory effects of 2-chloroethyl ethyl sulfide on redox cycling b cytochrome P450 reductase, spontaneous hydrogen peroxide production by the enzyme is stimulated by 2-chloroethyl ethyl sulfide. This response is concentration-dependent in the range of 0.1-10 mM, reaching a maximum at 0.3 mM | Homo sapiens | |
additional information | in contrast to the inhibitory effects of 2-chloroethyl ethyl sulfide on redox cycling b cytochrome P450 reductase, spontaneous hydrogen peroxide production by the enzyme is stimulated by 2-chloroethyl ethyl sulfide. This response is concentration-dependent in the range of 0.1-10 mM, reaching a maximum at 0.3 mM | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-chloroethyl ethyl sulfide | potent inhibitor | Homo sapiens | |
2-chloroethyl ethyl sulfide | potent inhibitor | Mus musculus | |
2-chloroethyl ethyl sulfide | potent inhibitor | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
MLE-15 cell | type II lung epithelial cell | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ferricytochrome c + NADPH | - |
Mus musculus | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
2 ferricytochrome c + NADPH | - |
Homo sapiens | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
2 ferricytochrome c + NADPH | - |
Rattus norvegicus | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol | - |
Mus musculus | NADP+ + reduced 2,6-dichlorophenolindophenol | - |
? | |
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol | - |
Homo sapiens | NADP+ + reduced 2,6-dichlorophenolindophenol | - |
? | |
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol | - |
Rattus norvegicus | NADP+ + reduced 2,6-dichlorophenolindophenol | - |
? | |
NADPH + H+ + oxidized menadione | - |
Mus musculus | NADP+ + reduced menadione | - |
? | |
NADPH + H+ + oxidized menadione | - |
Homo sapiens | NADP+ + reduced menadione | - |
? | |
NADPH + H+ + oxidized menadione | - |
Rattus norvegicus | NADP+ + reduced menadione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytochrome P450 reductase | - |
Mus musculus |
cytochrome P450 reductase | - |
Homo sapiens |
cytochrome P450 reductase | - |
Rattus norvegicus |
NADPH cytochrome P450 reductase | - |
Mus musculus |
NADPH cytochrome P450 reductase | - |
Homo sapiens |
NADPH cytochrome P450 reductase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Mus musculus | |
FAD | - |
Homo sapiens | |
FAD | - |
Rattus norvegicus | |
FMN | - |
Mus musculus | |
FMN | - |
Homo sapiens | |
FMN | - |
Rattus norvegicus | |
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.38 | - |
using ferricytochrome c as cosubstrate, in 10 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | 2-chloroethyl ethyl sulfide | |
1.9 | - |
using ferricytochrome c as cosubstrate, in 10 mM phosphate buffer (pH 7.4), at 37°C | Mus musculus | 2-chloroethyl ethyl sulfide | |
2.9 | - |
in 10 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | 2-chloroethyl ethyl sulfide | |
3.3 | - |
using oxidized 2,6-dichlorophenolindophenol as cosubstrate, in 10 mM phosphate buffer (pH 7.4), at 37°C | Mus musculus | 2-chloroethyl ethyl sulfide | |
8.6 | - |
using oxidized 2,6-dichlorophenolindophenol as cosubstrate, in 10 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | 2-chloroethyl ethyl sulfide |