Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A287P | the POR mutant is associated with 75-80% of normal heme oxygenase-1 activity | Homo sapiens |
A457H | the POR mutant is associated with total loss of heme oxygenase-1 activity | Homo sapiens |
A503V | the POR mutant is associated with close to wild type activity of heme oxygenase-1 | Homo sapiens |
C569Y | the POR mutant is associated with 75-80% of normal heme oxygenase-1 activity | Homo sapiens |
G413S | the POR mutant is associated with close to wild type activity of heme oxygenase-1 | Homo sapiens |
G504R | the POR mutant is associated with close to wild type activity of heme oxygenase-1 | Homo sapiens |
P228L | the POR mutant is associated with close to wild type activity of heme oxygenase-1 | Homo sapiens |
R316W | the POR mutant is associated with close to wild type activity of heme oxygenase-1 | Homo sapiens |
R616X | the POR mutant is associated with total loss of heme oxygenase-1 activity | Homo sapiens |
V492E | the POR mutant is associated with total loss of heme oxygenase-1 activity | Homo sapiens |
V608F | the POR mutant is associated with 75-80% of normal heme oxygenase-1 activity | Homo sapiens |
Y181D | the POR mutant is associated with total loss of heme oxygenase-1 activity | Homo sapiens |
Y459H | the POR mutant is associated with total loss of heme oxygenase-1 activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ferricytochrome P450 + NADPH | Homo sapiens | - |
2 ferrocytochrome P450 + NADP+ + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Q-Sepharose column chromatography and Superdex 200 gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ferricytochrome P450 + NADPH | - |
Homo sapiens | 2 ferrocytochrome P450 + NADP+ + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CPR | - |
Homo sapiens |
NADPH P450 reductase | - |
Homo sapiens |
POR | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
FMN | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | mutations in POR may reduce heme oxygenase-1 activity, potentially influencing heme catabolism in individuals carrying mutant POR alleles | Homo sapiens |