Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.6.2.4 extracted from

  • Weng, Y.; Fang, C.; Turesky, R.J.; Behr, M.; Kaminsky, L.S.; Ding, X.
    Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice (2007), Cancer Res., 67, 7825-7832.
    View publication on PubMed
Search for more literature for 1.6.2.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus CPR, the obligate electron donor for microsomal P450 enzymes, is essential for the bioactivation of many procarcinogens ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 a transgenic mouse model, with the NADPH-P450 reductase (Cpr) gene deleted in a lung-specific and doxycycline-inducible fashion (lung-Cpr-null)
-

Source Tissue

Source Tissue Comment Organism Textmining
lung the numbers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumors are reduced in the lung-Cpr-null mice but are increased in the liver-Cpr-null mice, relative to wild-type control mice Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CPR, the obligate electron donor for microsomal P450 enzymes, is essential for the bioactivation of many procarcinogens Mus musculus ?
-
 ?