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Literature summary for 1.6.2.4 extracted from
- Characterization of microsomal NADPH-dependent aldehyde reductase from rat brain (1986), J. Biochem., 99, 513-519.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| steapsin | brain | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
hexadecanal | - |
Rattus norvegicus |  |
| 0.21 | - |
octanal | - |
Rattus norvegicus | |
| 0.31 | - |
4-nitrobenzaldehyde | - |
Rattus norvegicus | |
| 1.4 | - |
4-Nitroacetophenone | - |
Rattus norvegicus | |
| 2.5 | - |
Benzalacetone | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Wistar strain | - |
| Rattus norvegicus Wistar | - |
Wistar strain | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| liver | phenobarbital-treated animals | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.02 | - |
brain | Rattus norvegicus |
| 0.211 | - |
brain, electron acceptor: hexadecanal | Rattus norvegicus |
| 5.9 | - |
brain, electron acceptor: p-nitrobenzaldehyde | Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -80°C | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 ferricytochrome c + NADPH | - |
Rattus norvegicus | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
| NADPH + H+ + 4-nitroacetophenone | - |
Rattus norvegicus | ? | - |
r | |
| NADPH + H+ + 4-nitrobenzaldehyde | - |
Rattus norvegicus | ? | - |
r | |
| NADPH + H+ + benzalacetone | - |
Rattus norvegicus | ? | - |
r | |
| NADPH + hexadecanal | brain, hexadecanal replaceable by p-nitroacetophenone, or p-pyridinecarboxaldehyde, benzalacetone or p-nitrobenzaldehyde | Rattus norvegicus | NADP+ + hexadecanol | - |
? | |
| NADPH + octanal | - |
Rattus norvegicus | NADP+ + octanol | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 75000-76000, SDS-PAGE | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
brain, inactivation | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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