Literature summary for 1.6.2.2 extracted from

Lamb, D.C.; Kelly, D.E.; Manning, N.J.; Kaderbhai, M.A.; Kelly, S.L.
Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction (1999), FEBS Lett., 462, 283-288.

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Cloned(Commentary)

Cloned (Comment)	Organism
heterologous expression in Saccharomyces cerevisiae	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Saccharomyces cerevisiae	5783	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2 ferricytochrome b5 + NADH	Saccharomyces cerevisiae	enzyme complex drives the entire sterol 14-demethylation reaction	2 ferrocytochrome b5 + NAD+ + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 ferricytochrome b5 + NADH	enzyme complex drives the entire sterol 14-demethylation reaction	Saccharomyces cerevisiae	2 ferrocytochrome b5 + NAD+ + H+	-	?

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Release 2023.1 (January 2023)