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Literature summary for 1.6.1.2 extracted from

  • Houghton, R.L.; Fisher, R.R.; Sanadi, D.R.
    Dependence of Escherichia coli pyridine nucleotide transhydrogenase on phospholipids and its sensitivity (1976), Biochem. Biophys. Res. Commun., 73, 751-757.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
asolectin 10fold stimulation of partially purified enzyme Escherichia coli
cardiolipin 10fold stimulation of partially purified enzyme with Escherichia coli cardiolipin Escherichia coli
lecithin 5fold stimulation of partially purified enzyme Escherichia coli
Phospholipids approx. 15fold stimulation of partially purified enzyme with crude Escherichia coli lipid fraction Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
glutathione protection by NADP+ or NAD+, presence of NADPH accelerates inhibition Escherichia coli
methylmethane thiosulfonate 10 mM, approx. 80% inactivation after 320 min, approx. 40% in the presence of NADP+ or NAD+, approx. 90% in the presence of NADPH Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially purified Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
13.6
-
partially purified enzyme, assay in the presence of Escherichia coli phospholipids Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Escherichia coli
NADH
-
Escherichia coli
NADP+
-
Escherichia coli
NADPH
-
Escherichia coli