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Literature summary for 1.6.1.2 extracted from

  • Rydström, J.; Hoek, J.B.; Ernster, L.
    Nicotinamide nucleotide transhydrogenases (1976), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 13, 51-88.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
2'-AMP
-
Bos taurus
2'-AMP
-
Mammalia
3'-5'-AMP
-
Mammalia
3'-AMP
-
Mammalia
5'-AMP
-
Mammalia
acetyl-CoA
-
Mammalia
acetyl-dephospho-CoA competitive vs. NAD(H) Mammalia
adenosine
-
Mammalia
ADP
-
Mammalia
Ca2+
-
Bos taurus
Ca2+
-
Mammalia
CoA
-
Bos taurus
CoA
-
Mammalia
D2O
-
Mammalia
dephospho-CoA competitive vs. NAD(H) Mammalia
Mg2+
-
Bos taurus
Mg2+
-
Mammalia
Mn2+
-
Bos taurus
Mn2+
-
Mammalia
palmitoyl-CoA
-
Bos taurus
palmitoyl-CoA
-
Mammalia
triiodothyronine
-
Bos taurus
triiodothyronine
-
Mammalia

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.009
-
NADH
-
Bos taurus
0.02
-
NADPH
-
Bos taurus
0.028
-
NAD+
-
Bos taurus
0.04
-
NADP+
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
Mammalia 31966
-
mitochondrial membrane
-
Bos taurus 31966
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + NADP+ Mammalia
-
NADPH + NAD+
-
r
NADH + NADP+ Bos taurus
-
NADPH + NAD+
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Mammalia
-
-
-

Reaction

Reaction Comment Organism Reaction ID
NADPH + NAD+ = NADP+ + NADH mechanism Mammalia
NADPH + NAD+ = NADP+ + NADH mechanism Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
artery
-
Mammalia
-
artery
-
Bos taurus
-
heart
-
Mammalia
-
heart
-
Bos taurus
-
kidney
-
Bos taurus
-
liver
-
Mammalia
-
liver
-
Bos taurus
-
additional information no or low activity in brain, prostate, seminal vesicle, spleen, testis Mammalia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + NADP+ specific for 4A site of NADH, i.e. pro-R hydrogen and 4B site of NADPH, i.e. pro-S hydrogen Mammalia NAD+ + NADPH
-
?
NADH + NADP+ specific for 4A site of NADH, i.e. pro-R hydrogen and 4B site of NADPH, i.e. pro-S hydrogen Bos taurus NAD+ + NADPH
-
?
NADH + NADP+ inactive against 3'-analogs of NADP+ Mammalia NAD+ + NADPH
-
?
NADH + NADP+
-
Mammalia NADPH + NAD+
-
r
NADH + NADP+
-
Bos taurus NADPH + NAD+
-
r
NADH + thio-NADP+
-
Mammalia NAD+ + thio-NADPH
-
r
NADH + thio-NADP+
-
Bos taurus NAD+ + thio-NADPH
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
reduction of NADP+ Mammalia
7
-
-
Bos taurus
7
-
reduction of NAD+ Mammalia

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mammalia
NAD+
-
Bos taurus
NADH
-
Mammalia
NADH
-
Bos taurus
NADP+
-
Mammalia
NADP+
-
Bos taurus
NADPH
-
Mammalia
NADPH
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00015
-
palmitoyl-CoA
-
Mammalia
0.009
-
dephospho-CoA
-
Mammalia
0.011
-
acetyl-dephospho-CoA
-
Mammalia
0.2
-
CoA
-
Mammalia
0.2
-
CoA
-
Bos taurus
0.2
-
acetyl-CoA
-
Mammalia
0.3
-
ADP
-
Mammalia
0.3
-
5'-AMP
-
Mammalia
0.4
-
3'-5'-AMP
-
Mammalia
0.5
-
adenosine
-
Mammalia
0.7
-
3'-AMP
-
Mammalia
0.7
-
2'-AMP
-
Mammalia