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Literature summary for 1.5.99.5 extracted from

  • Latypova, E.; Yang, S.; Wang, Y.S.; Wang, T.; Chavkin, T.A.; Hackett, M.; Schaefer, H.; Kalyuzhnaya, M.G.
    Genetics of the glutamate-mediated methylamine utilization pathway in the facultative methylotrophic beta-proteobacterium Methyloversatilis universalis FAM5 (2010), Mol. Microbiol., 75, 426-439.
    View publication on PubMed
Search for more literature for 1.5.99.5

Cloned(Commentary)

Cloned (Comment) Organism
genes mgdA, mgdB, and mgdC, encoding subunits A, B, and large subunit c, the enzyme is encoded in a gene cluster essential for operation of the N-methylglutamate pathway, genetic structure Methyloversatilis universalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-methyl-L-glutamate + acceptor + H2O Methyloversatilis universalis
-
 L-glutamate + formaldehyde + reduced acceptor
-
 ?
N-methyl-L-glutamate + acceptor + H2O Methyloversatilis universalis FAM5
-
 L-glutamate + formaldehyde + reduced acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Methyloversatilis universalis
-
 genes mgdA, mgdB, and mgdC, encoding subunits A, B, and large subunit c
-
Methyloversatilis universalis FAM5
-
 genes mgdA, mgdB, and mgdC, encoding subunits A, B, and large subunit c
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-methyl-L-glutamate + acceptor + H2O
-
 Methyloversatilis universalis L-glutamate + formaldehyde + reduced acceptor
-
 ?
N-methyl-L-glutamate + acceptor + H2O
-
 Methyloversatilis universalis FAM5 L-glutamate + formaldehyde + reduced acceptor
-
 ?
N-methyl-L-glutamate + oxidized 2,6-dichlorophenolindophenol + H2O
-
 Methyloversatilis universalis L-glutamate + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
 ?
N-methyl-L-glutamate + oxidized 2,6-dichlorophenolindophenol + H2O
-
 Methyloversatilis universalis FAM5 L-glutamate + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
 ?

Subunits

Subunits Comment Organism
? subunits A, B, and large subunit c Methyloversatilis universalis

Synonyms

Synonyms Comment Organism
N-methyl-L-glutamate:oxidoreductase
-
 Methyloversatilis universalis
N-methylglutamate dehydrogenase
-
 Methyloversatilis universalis
NMGDH
-
 Methyloversatilis universalis

General Information

General Information Comment Organism
metabolism SoxBDAG, encoding sarcosine dehydrogenase,may be involved in oxidation of N-methyl-L-glutamate, overview Methyloversatilis universalis
additional information the enzyme is encoded in a gene cluster essential for operation of the N-methylglutamate pathway in the methylotrophic beta-proteobacterium Methyloversatilis universalis FAM5. The enzyme contains an aminomethyltransferase folate-binding domain near the C-terminus of its large subunit Methyloversatilis universalis