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Literature summary for 1.5.8.3 extracted from

  • Eschenbrenner, M.; Schuman Jorns, M.
    Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia (1999), Genomics, 59, 300-308.
    View publication on PubMed
Search for more literature for 1.5.8.3

Application

Application Comment Organism
medicine sarcosine dehydrogenase is defective in patient with sarcosinemia Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
99505
-
 1 * 99505 Homo sapiens
99510
-
 including covalently bound FAD Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sarcosine + acceptor + H2O Homo sapiens acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate glycine + formaldehyde + reduced acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney adult and fetal Homo sapiens
-
liver adult and fetal Homo sapiens
-
pancreas
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sarcosine + acceptor + H2O acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate Homo sapiens glycine + formaldehyde + reduced acceptor
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 99505 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD covalent bound FAD linked via 8a-position of the isoalloxazin ring to the imidazole N(3) of a histidine residue, structural homology between the amino acid sequence of the flavin-peptides Homo sapiens
tetrahydrofolate
-
 Homo sapiens