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Literature summary for 1.5.8.3 extracted from
- Sarcosine dehydrogenase and dimethylglycine dehydrogenase (rat liver, monkey liver) (1970), Methods Enzymol., 17A, 976-981.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Methoxyacetate | - |
Macaca mulatta |  |
| Methoxyacetate | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.32 | 1 | sarcosine | - |
Rattus norvegicus | |
| 0.32 | 1 | sarcosine | - |
Macaca mulatta | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Macaca mulatta | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | - |
Macaca mulatta | |
| Fe2+ | the enzyme contains 1-2 atoms non-heme iron per 300000 g of protein | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sarcosine + acceptor + H2O | Rattus norvegicus | acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate | glycine + formaldehyde + reduced acceptor | - |
? | |
| sarcosine + acceptor + H2O | Macaca mulatta | acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate | glycine + formaldehyde + reduced acceptor | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Macaca mulatta | - |
monkey | - |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Macaca mulatta |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| liver | - |
Macaca mulatta | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -4°C, lyophilized, 1 week | Rattus norvegicus |
| -4°C, lyophilized, 1 week | Macaca mulatta |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sarcosine + acceptor + H2O | acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate | Rattus norvegicus | glycine + formaldehyde + reduced acceptor | - |
? | |
| sarcosine + acceptor + H2O | acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate | Macaca mulatta | glycine + formaldehyde + reduced acceptor | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
sarcosine + phenazine methosulfate | Rattus norvegicus |
| 8 | - |
sarcosine + phenazine methosulfate | Macaca mulatta |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.1 | - |
Methoxyacetate | reversible,competitive | Macaca mulatta | |
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Release 2023.1 (January 2023)
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