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Literature summary for 1.5.3.16 extracted from
- Spermine oxidase is upregulated and promotes tumor growth in hepatocellular carcinoma (2018), Hepatol. Res., 48, 967-977 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | SMOX is overexpressed in hepatocellular carcinoma cell lines and clinical hepatocellular carcinoma tissues. SMOX expression levels are gradually increased in normal liver, chronic hepatitis, and hepatocellular carcinoma tissues. Increased SMOX expression is correlated with poor clinical features of hepatocellular carcinoma. Positive SMOX expression in tumor tissues indicate worse overall survival of patients and shorter relapse-free survival. Knockdown of SMOX inhibits hepatocellular carcinoma cell proliferation, arrested cell cycle at S phase, and results in an increase of apoptosis | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9NWM0 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| carcinoma cell | hepatocellular carcinoma cell | Homo sapiens | - |
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Release 2023.1 (January 2023)
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