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Literature summary for 1.5.3.16 extracted from

  • Cervelli, M.; Polticelli, F.; Fiorucci, L.; Angelucci, E.; Federico, R.; Mariottini, P.
    Inhibition of acetylpolyamine and spermine oxidases by the polyamine analogue chlorhexidine (2013), J. Enzyme Inhib. Med. Chem., 28, 463-467 .
No PubMed abstract available
Search for more literature for 1.5.3.16

Application

Application Comment Organism
medicine the selective inhibitors of spermine oxidase represent an important tool for the development of novel anti-neoplastic drugs Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Chlorhexidine poor inhibitor Mus musculus
N,N'-bis(2,3-butadienyl)-1,4-butanediamine i.e. MDL 72527. Binding of the inhibitor to the enzyme takes place essentially only through a hydrophobic interaction with Trp62 side chain Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.09
-
 spermine pH 8.3, 25°C Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
spermine + O2 + H2O Mus musculus the enzyme is involved in the catabolism of polyamines spermidine + 3-aminopropanal + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q99K82
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
spermine + O2 + H2O
-
 Mus musculus spermidine + 3-aminopropanal + H2O2
-
 ?
spermine + O2 + H2O the enzyme is involved in the catabolism of polyamines Mus musculus spermidine + 3-aminopropanal + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
SMO
-
 Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.5
-
 spermine pH 8.3, 25°C Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00055
-
 Chlorhexidine pH 8.3, 25°C Mus musculus

General Information

General Information Comment Organism
metabolism the enzyme is involved in the catabolism of polyamines Mus musculus