Literature summary for 1.5.3.16 extracted from

Bongers, K.S.; Fox, D.K.; Kunkel, S.D.; Stebounova, L.V.; Murry, D.J.; Pufall, M.A.; Ebert, S.M.; Dyle, M.C.; Bullard, S.A.; Dierdorff, J.M.; Adams, C.M.
Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy (2015), Am. J. Physiol. Endocrinol. Metab., 308, E144-E158 .

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Application

Application	Comment	Organism
medicine	spermine oxidase is an important positive regulator of muscle fiber size whose expression is strongly downregulated by conditions that cause muscle atrophy. This reduction in spermine oxidase enables the atrophy process and represents a potential target for therapeutic intervention	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q99K82	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skeletal muscle	-	Mus musculus	-

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	reduced spermine oxidase expression may contribute to muscle atrophy during a variety of stress conditions, including immobilization, denervation, fasting, and aging	Mus musculus
physiological function	spermine oxidase as an important positive regulator of muscle gene expression and fiber size	Mus musculus

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Release 2023.1 (January 2023)