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Literature summary for 1.5.3.16 extracted from

  • Wang, Y.; Devereux, W.; Woster, P.M.; Stewart, T.M.; Hacker, A.; Casero, R.A., Jr.
    Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure (2001), Cancer Res., 61, 5370-5373.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N1,N4-bis(2,3-butadienyl)-1,4-butanediamine i.e. MDL72527 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
spermine 37°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
62000
-
x * 62000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PAOh1 is upregulated in response to polyamine analogue exposure. N1,N11-bis(ethyl)norspermine results in 5fold induction of PAO mRNA and a more than 3-fold induction of PAO activity ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NWM0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PAOh1 is upregulated in response to polyamine analogue exposure. N1,N11-bis(ethyl)norspermine results in 5fold induction of PAO mRNA and a more than 3-fold induction of PAO activity Homo sapiens ?
-
?
spermine + O2 + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 62000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PAOh1
-
Homo sapiens