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Literature summary for 1.5.3.13 extracted from
- Highly expressed N1-acetylpolyamine oxidase detoxifies polyamine analogue N1-cyclopropylmethyl-N11-ethylnorspermine in human lung cancer cell line A549 (2009), Chin. Med. Sci., 122, 1394-1399.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | high expression of APAO in A549 cells inhibits accumulation of antitumor polyamine analogue, N1-cyclopropylmethyl-N11-ethylnorspermine, decreases their sensitivity to the toxicity of N1-cyclopropylmethyl-N11-ethylnorspermine and prevents N1-cyclopropylmethyl-N11-ethylnorspermine-induced apoptosis | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transfection of A-549 cell | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N1-cyclopropylmethyl-N11-ethylnorspermine + O2 + H2O | - |
Homo sapiens | ? | - |
? |  |
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