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Literature summary for 1.5.3.13 extracted from
- Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity (2005), Cancer Chemother. Pharmacol., 56, 83-90.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| stable expression of hPAO-1 in A549 cell line | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N1,N4-bis(2,3-butadienyl)-1,4-butanediamine | i.e. MDL 72,527 | Homo sapiens |  |
| SL-11144 | 0.01 mM, 80% inhibition | Homo sapiens | |
| SL-11150 | 0.01 mM, complete inhibition | Homo sapiens | |
| SL-11158 | 0.01 mM, complete inhibition | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00085 | - |
N1-acetylspermine | pH 8.0 | Homo sapiens | |
| 0.0021 | - |
N1-acetylspermidine | pH 8.0 | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q6QHF9 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-N1-(2-methyl-1-butyl)-N11-ethyl-4,8-diazaundecane-1,11-diamine + O2 + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | no efficient hydrolysis of: spermine, spermidine and N8-acetylspermidine, SL-11144, SL-11150, SL-11158 and SL-11156 | Homo sapiens | ? | - |
? | |
| N1,N12-diacetylspermine + O2 + H2O | - |
Homo sapiens | ? | - |
? | |
| N1-acetylspermidine + O2 + H2O | - |
Homo sapiens | ? | - |
? | |
| N1-acetylspermine + O2 + H2O | - |
Homo sapiens | ? | - |
? | |
| N1-ethyl-N11-(cycloheptyl)methyl-4,8-diazaundecane-1,11-diamine + O2 + H2O | - |
Homo sapiens | ? | - |
? | |
| N1-ethyl-N11-(cyclopropyl)methyl-4,8-diazaundecane + O2 + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hPAO-1 | - |
Homo sapiens |
| N1-acetylpolyamine oxidase | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 15 | - |
N1-acetylspermidine | pH 8.0 | Homo sapiens | |
| 31.7 | - |
N1-acetylspermine | pH 8.0 | Homo sapiens | |
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