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Literature summary for 1.5.1.34 extracted from

  • Chen, C.; Kim, H.L.; Zhuang, N.; Seo, K.H.; Park, K.H.; Han, C.D.; Park, Y.S.; Lee, K.H.
    Structural insights into the dual substrate specificities of mammalian and Dictyostelium dihydropteridine reductases toward two stereoisomers of quinonoid dihydrobiopterin (2011), FEBS Lett., 585, 2640-2646.
    View publication on PubMed
Search for more literature for 1.5.1.34

Crystallization (Commentary)

Crystallization (Comment) Organism
complexed with NAD+, hanging drop vapor diffusion method, using 17% (w/v) polyethylene glycol 3350 and 100 mM Bis-Tris at pH 6.5 Dictyostelium discoideum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04651
-
 NADH apparent value, in 50 mM Tris-HCl, pH 7.5, at 25°C Dictyostelium discoideum

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum Q86A17
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel-affinity column chromatography Dictyostelium discoideum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6R)-L-erythro-dihydrobiopterin + NADH + H+
-
 Dictyostelium discoideum ?
-
 ?
6,7-dimethyldihydropterin + NADH + H+
-
 Dictyostelium discoideum 6,7-dimethyltetrahydropterin + NAD+
-
 ?
quinonoid (6R)-D-threo-dihydrobiopterin + NADH + H+
-
 Dictyostelium discoideum ?
-
 ?

Synonyms

Synonyms Comment Organism
DHPR
-
 Dictyostelium discoideum

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Dictyostelium discoideum