Literature summary for 1.5.1.34 extracted from

Gu, Y.; Gong, Y.; Zhang, H.; Dong, X.; Zhao, T.; Burczynski, F.J.; Wang, G.; Sun, S.; Zhu, B.; Han, W.; Wang, H.; Li, P.
Regulation of transforming growth factor beta 1 gene expression by dihydropteridine reductase in kidney 293T cells (2013), Biochem. Cell Biol., 91, 187-193.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293T cells	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
renal cortex	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
QDPR	-	Rattus norvegicus
quinoid dihydropteridine reductase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	enzyme expression is significantly decreased in the renal cortex of diabetic rats	down

General Information

General Information	Comment	Organism
malfunction	enzyme inhibition results in a significant increase in transforming growth factor-beta1 expression	Rattus norvegicus
physiological function	the enzyme is an important factor mediating diabetic nephropathy through its regulation of transforming growth factor-beta1/Smad3 signaling and NADPH oxidase	Rattus norvegicus

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Release 2023.1 (January 2023)