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Literature summary for 1.5.1.34 extracted from

  • Lind, K.E.
    Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines (1972), Eur. J. Biochem., 25, 560-562.
    View publication on PubMed
Search for more literature for 1.5.1.34

Inhibitors

Inhibitors Comment Organism Structure
2,4-diamino-7,8-dihydropteroylglutamic acid
-
 Rattus norvegicus
2,4-Diaminopteridine
-
 Rattus norvegicus
2,4-diaminopteroic acid
-
 Rattus norvegicus
2,4-diaminopteroylglutamic acid
-
 Rattus norvegicus
quinonoid 2,4-diamino-7,8-dihydropteroylglutamic acid
-
 Rattus norvegicus
quiononoid 2,4-diamino-7,8-dihydropteroylglutamic acid
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
-
 Rattus norvegicus 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
-
 ?
2-amino-4-hydroxy-6-methyl-dihydropteridine + NAD(P)H
-
 Rattus norvegicus 2-amino-4-hydroxy-6-methyl-tetrahydropteridine + NAD(P)+
-
 ?
2-amino-4-hydroxy-7-methyl-dihydropteridine + NAD(P)H
-
 Rattus norvegicus 2-amino-4-hydroxy-7-methyl-tetrahydropteridine + NAD(P)+
-
 ?
dihydropteroic acid + NAD(P)H
-
 Rattus norvegicus tetrahydropteroate + NAD(P)+
-
 ?
dihydropteroylglutamic acid + NAD(P)H
-
 Rattus norvegicus tetrahydropteroylglutamate + NAD(P)+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADH utilizes both NADH and NADPH Rattus norvegicus
NADPH utilizes both NADH and NADPH Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.022
-
 quinonoid 2,4-diamino-7,8-dihydropteroylglutamic acid
-
 Rattus norvegicus
0.023
-
 2,4-diamino-7,8-dihydropteroylglutamic acid
-
 Rattus norvegicus
0.024
-
 2,4-diaminopteroylglutamic acid
-
 Rattus norvegicus
0.0295
-
 2,4-diaminopteroic acid
-
 Rattus norvegicus