Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methotrexate | - |
Ovis aries |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0009 | - |
tetrahydrobiopterin | cofactor NADPH | Ovis aries | |
0.001 | - |
tetrahydrobiopterin | cofactor NADH | Ovis aries | |
0.0011 | - |
tetrahydrobiopterin | - |
Homo sapiens | |
0.0011 | - |
tetrahydrobiopterin | - |
Rattus norvegicus | |
0.0022 | - |
NADH | - |
Rattus norvegicus | |
0.004 | - |
NADH | substrate tetrahydrobiopterin | Ovis aries | |
0.0057 | - |
NADH | substrate 6,7-dimethyl-5,6,7,8-tetrahydrobiopterin | Ovis aries | |
0.0063 | - |
6,7-dimethyl-5,6,7,8-tetrahydrobiopterin | cofactor NADPH | Ovis aries | |
0.008 | - |
NADH | - |
Homo sapiens | |
0.0152 | - |
6,7-dimethyl-5,6,7,8-tetrahydrobiopterin | cofactor NADH | Ovis aries | |
0.0709 | - |
NADPH | substrate tetrahydrobiopterin | Ovis aries | |
0.0806 | - |
NADPH | substrate 6,7-dimethyl-5,6,7,8-tetrahydrobiopterin | Ovis aries | |
0.1 | - |
NADPH | - |
Rattus norvegicus | |
0.11 | - |
NADPH | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
21000 | - |
2 * 21000, liver, SDS-PAGE | Ovis aries |
41000 | - |
gradient PAGE | Ovis aries |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Ovis aries | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Ovis aries |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal medulla | - |
Ovis aries | - |
brain | - |
Homo sapiens | - |
brain | - |
Ovis aries | - |
kidney | - |
Ovis aries | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Ovis aries | - |
spleen | - |
Ovis aries | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.51 | - |
- |
Homo sapiens |
3.64 | - |
- |
Rattus norvegicus |
15.6 | - |
- |
Ovis aries |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6,7-dihydropteridine + NADH | - |
Homo sapiens | (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+ | - |
? | |
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD+ | - |
Ovis aries | 6,7-dimethyl-7,8-dihydropterin + NADH + H+ | - |
r | |
6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+ | - |
Ovis aries | 6,7-dimethyl-7,8-dihydropterin + NADPH + H+ | - |
r | |
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H | - |
Ovis aries | 5,6,7,8-tetrahydrobiopterin + NAD(P)+ | - |
? | |
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H | enzyme prefers NADH | Ovis aries | 5,6,7,8-tetrahydrobiopterin + NAD(P)+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Homo sapiens |
dimer | - |
Rattus norvegicus |
dimer | 2 * 21000, liver, SDS-PAGE | Ovis aries |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | utilizes both NADH and NADPH | Homo sapiens | |
NADH | utilizes both NADH and NADPH | Rattus norvegicus | |
NADH | utilizes both NADH and NADPH | Ovis aries | |
NADH | enzyme prefers NADH | Homo sapiens | |
NADH | enzyme prefers NADH | Rattus norvegicus | |
NADH | enzyme prefers NADH | Ovis aries | |
NADPH | utilizes both NADH and NADPH | Homo sapiens | |
NADPH | utilizes both NADH and NADPH | Rattus norvegicus | |
NADPH | utilizes both NADH and NADPH | Ovis aries | |
NADPH | NADH is preferred | Homo sapiens | |
NADPH | NADH is preferred | Rattus norvegicus | |
NADPH | NADH is preferred | Ovis aries |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.038 | - |
methotrexate | - |
Ovis aries |