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Literature summary for 1.5.1.33 extracted from

  • Singh, N.; Kaur, J.; Kumar, P.; Gupta, S.; Singh, N.; Ghosal, A.; Dutta, A.; Kumar, A.; Tripathi, R.; Siddiqi, M.I.; Mandal, C.; Dube, A.
    An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1 (2009), Parasitol. Res., 105, 1317-1325.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
overexpressed in transgenic Leishmania parasites as N-terminal GFP-tagged PTR1-green fluorescent protein Leishmania donovani

Inhibitors

Inhibitors Comment Organism Structure
(4-fluoro-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester treatment with 98 microM resulted in reduction of viable cells from 96.5% (control) to 9.86% after 5 h Leishmania donovani

Organism

Organism UniProt Comment Textmining
Leishmania donovani
-
-
-

Synonyms

Synonyms Comment Organism
pteridine reductase 1
-
 Leishmania donovani
PTR1
-
 Leishmania donovani