Literature summary for 1.5.1.30 extracted from

Cunningham, O.; Gore, M.G.; Mantle, T.J.
Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B) (2000), Biochem. J., 345, 393-399.

Search for more literature for 1.5.1.30

Inhibitors

Inhibitors	Comment	Organism	Structure
lumichrome	competitive inhibitor against FMN and a mixed inhibitor of NADPH	Homo sapiens
mesobiliverdin XIIIa	competitive kinetics with FMN and mixed inhibition kinetics with NADPH	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.052	-	FMN	pH 7.5, 25°C	Homo sapiens
0.053	-	oxidized riboflavin	pH 7.5, 25°C	Homo sapiens
0.125	-	FAD	pH 7.5, 25°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P30043	bifunctional enzyme biliverdin reductase/flavin reductase (NADPH)	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
FAD + NADPH + H+	-	Homo sapiens	FADH2 + NADP+	-	?
FMN + NADPH + H+	-	Homo sapiens	FMNH2 + NADP+	-	?
oxidized riboflavin + NADPH + H+	-	Homo sapiens	reduced riboflavin + NADP+	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.099	-	FMN	pH 7.5, 25°C	Homo sapiens
0.3	-	FAD	pH 7.5, 25°C	Homo sapiens
0.3	-	oxidized riboflavin	pH 7.5, 25°C	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5	-	sharp optimum, in citrate buffer	Homo sapiens
7.5	-	assay at	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00059	-	mesobiliverdin XIIIa	pH 7.5, 25°C	Homo sapiens
0.076	-	lumichrome	pH 7.5, 25°C	Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
1.9	-	FMN	pH 7.5, 25°C	Homo sapiens
2.4	-	FAD	pH 7.5, 25°C	Homo sapiens
5.6	-	oxidized riboflavin	pH 7.5, 25°C	Homo sapiens

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Release 2023.1 (January 2023)