Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for drug development since the organism causes the opportunistic infection Pneumocystis pneumonia, a major cause of mortality in acquired immunodeficiency syndrome, AIDS, patients | Pneumocystis carinii |
drug development | the enzyme is a target for drug development since the organism causes the opportunistic infection toxoplasmosis, a major cause of mortality in acquired immunodeficiency syndrome, AIDS, patients | Toxoplasma gondii |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,4-diamino-6-[N-(2,3,5-trichlorobenzyl)-N-ethylamino]quinazoline | - |
Pneumocystis carinii | |
2,4-diamino-6-[N-(2,3,5-trichlorobenzyl)-N-ethylamino]quinazoline | - |
Toxoplasma gondii | |
2,4-diamino-6-[N-(2,5-dimethoxybenzyl)-N-cyclopropyl methylamino]quinazoline | - |
Pneumocystis carinii | |
2,4-diamino-6-[N-(2,5-dimethoxybenzyl)-N-cyclopropyl methylamino]quinazoline | - |
Toxoplasma gondii | |
2,4-diamino-6-[N-(2,5-dimethoxybenzyl)-N-ethylamino]quinazoline | - |
Pneumocystis carinii | |
2,4-diamino-6-[N-(2,5-dimethoxybenzyl)-N-ethylamino]quinazoline | - |
Toxoplasma gondii | |
2,4-diamino-6-[N-(2,5-dimethoxybenzyl)-N-propylamino]quinazoline | - |
Pneumocystis carinii | |
2,4-diamino-6-[N-(2,5-dimethoxybenzyl)-N-propylamino]quinazoline | - |
Toxoplasma gondii | |
2,4-diamino-6-[N-(alpha-naphthyl)-N-ethylamino]quinazoline | - |
Pneumocystis carinii | |
2,4-diamino-6-[N-(alpha-naphthyl)-N-ethylamino]quinazoline | - |
Toxoplasma gondii | |
2,4-diamino-6-[N-(benzyl)-N-ethylamino]quinazoline | - |
Pneumocystis carinii | |
2,4-diamino-6-[N-(benzyl)-N-ethylamino]quinazoline | - |
Toxoplasma gondii | |
2,4-diamino-6-[N-(beta-naphthyl)-N-cyclopropyl methylamino]-quinazoline | - |
Pneumocystis carinii | |
2,4-diamino-6-[N-(beta-naphthyl)-N-cyclopropyl methylamino]-quinazoline | - |
Toxoplasma gondii | |
2,4-diamino-6-[N-(beta-naphthyl)-N-ethylamino]quinazoline | - |
Pneumocystis carinii | |
2,4-diamino-6-[N-(beta-naphthyl)-N-ethylamino]quinazoline | - |
Toxoplasma gondii | |
2,4-diamino-6-[N-(beta-naphthyl)-N-propylamino]quinazoline | - |
Pneumocystis carinii | |
2,4-diamino-6-[N-(beta-naphthyl)-N-propylamino]quinazoline | - |
Toxoplasma gondii | |
additional information | inhibitor design and synthesis, overview | Pneumocystis carinii | |
additional information | inhibitor design and synthesis, overview | Toxoplasma gondii | |
N6-(2,5-dimethoxybenzyl)-N6-methylpyrido[2,3-d]pyrimidine-2,4,6-triamine | - |
Pneumocystis carinii | |
N6-(2,5-dimethoxybenzyl)-N6-methylpyrido[2,3-d]pyrimidine-2,4,6-triamine | - |
Toxoplasma gondii | |
N6-(2,5-dimethoxybenzyl)-N6-methylquinazoline-2,4,6-triamine | - |
Pneumocystis carinii | |
N6-(2,5-dimethoxybenzyl)-N6-methylquinazoline-2,4,6-triamine | - |
Toxoplasma gondii | |
N6-(2,5-dimethoxybenzyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine | - |
Pneumocystis carinii | |
N6-(2,5-dimethoxybenzyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine | - |
Toxoplasma gondii | |
N6-(2,5-dimethoxybenzyl)quinazoline-2,4,6-triamine | - |
Pneumocystis carinii | |
N6-(2,5-dimethoxybenzyl)quinazoline-2,4,6-triamine | - |
Toxoplasma gondii | |
trimethoprim | - |
Pneumocystis carinii | |
trimethoprim | - |
Toxoplasma gondii | |
trimetrexate | - |
Pneumocystis carinii | |
trimetrexate | - |
Toxoplasma gondii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH + H+ | Pneumocystis carinii | - |
5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH + H+ | Toxoplasma gondii | - |
5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pneumocystis carinii | - |
- |
- |
Toxoplasma gondii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH + H+ | - |
Pneumocystis carinii | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH + H+ | - |
Toxoplasma gondii | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHFR | - |
Pneumocystis carinii |
DHFR | - |
Toxoplasma gondii |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Pneumocystis carinii |
37 | - |
assay at | Toxoplasma gondii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Pneumocystis carinii | |
NADPH | - |
Toxoplasma gondii |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000025 | - |
- |
Pneumocystis carinii | 2,4-diamino-6-[N-(alpha-naphthyl)-N-ethylamino]quinazoline | |
0.0000036 | - |
- |
Toxoplasma gondii | 2,4-diamino-6-[N-(benzyl)-N-ethylamino]quinazoline | |
0.0000037 | - |
- |
Toxoplasma gondii | 2,4-diamino-6-[N-(2,5-dimethoxybenzyl)-N-ethylamino]quinazoline | |
0.0000063 | - |
- |
Toxoplasma gondii | N6-(2,5-dimethoxybenzyl)-N6-methylpyrido[2,3-d]pyrimidine-2,4,6-triamine | |
0.0000069 | - |
- |
Pneumocystis carinii | 2,4-diamino-6-[N-(2,3,5-trichlorobenzyl)-N-ethylamino]quinazoline | |
0.0000072 | - |
- |
Pneumocystis carinii | 2,4-diamino-6-[N-(beta-naphthyl)-N-ethylamino]quinazoline | |
0.0000073 | - |
- |
Toxoplasma gondii | 2,4-diamino-6-[N-(2,5-dimethoxybenzyl)-N-cyclopropyl methylamino]quinazoline | |
0.0000078 | - |
- |
Toxoplasma gondii | 2,4-diamino-6-[N-(alpha-naphthyl)-N-ethylamino]quinazoline | |
0.0000095 | - |
- |
Toxoplasma gondii | 2,4-diamino-6-[N-(2,5-dimethoxybenzyl)-N-propylamino]quinazoline | |
0.0000099 | - |
- |
Pneumocystis carinii | 2,4-diamino-6-[N-(2,5-dimethoxybenzyl)-N-ethylamino]quinazoline | |
0.000012 | - |
- |
Toxoplasma gondii | 2,4-diamino-6-[N-(beta-naphthyl)-N-ethylamino]quinazoline | |
0.000019 | - |
- |
Toxoplasma gondii | 2,4-diamino-6-[N-(2,3,5-trichlorobenzyl)-N-ethylamino]quinazoline | |
0.000019 | - |
- |
Toxoplasma gondii | 2,4-diamino-6-[N-(beta-naphthyl)-N-propylamino]quinazoline | |
0.000021 | - |
- |
Pneumocystis carinii | 2,4-diamino-6-[N-(benzyl)-N-ethylamino]quinazoline | |
0.000025 | - |
- |
Pneumocystis carinii | 2,4-diamino-6-[N-(2,5-dimethoxybenzyl)-N-cyclopropyl methylamino]quinazoline | |
0.000025 | - |
- |
Toxoplasma gondii | 2,4-diamino-6-[N-(beta-naphthyl)-N-cyclopropyl methylamino]-quinazoline | |
0.000027 | - |
- |
Pneumocystis carinii | 2,4-diamino-6-[N-(beta-naphthyl)-N-propylamino]quinazoline | |
0.00003 | - |
- |
Toxoplasma gondii | N6-(2,5-dimethoxybenzyl)-N6-methylquinazoline-2,4,6-triamine | |
0.000038 | - |
- |
Pneumocystis carinii | 2,4-diamino-6-[N-(2,5-dimethoxybenzyl)-N-propylamino]quinazoline | |
0.000042 | - |
- |
Pneumocystis carinii | 2,4-diamino-6-[N-(beta-naphthyl)-N-cyclopropyl methylamino]-quinazoline | |
0.000084 | - |
- |
Pneumocystis carinii | N6-(2,5-dimethoxybenzyl)-N6-methylpyrido[2,3-d]pyrimidine-2,4,6-triamine | |
0.000087 | - |
- |
Pneumocystis carinii | N6-(2,5-dimethoxybenzyl)-N6-methylquinazoline-2,4,6-triamine | |
0.00016 | - |
- |
Toxoplasma gondii | N6-(2,5-dimethoxybenzyl)quinazoline-2,4,6-triamine | |
0.00031 | - |
- |
Toxoplasma gondii | N6-(2,5-dimethoxybenzyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine | |
0.0038 | - |
- |
Pneumocystis carinii | N6-(2,5-dimethoxybenzyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine | |
0.0046 | - |
- |
Pneumocystis carinii | N6-(2,5-dimethoxybenzyl)quinazoline-2,4,6-triamine |