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Literature summary for 1.5.1.3 extracted from

  • Bowker, K.E.; Caspers, P.; Gaucher, B.; MacGowan, A.P.
    In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of Gram-positive bacteria (2009), Antimicrob. Agents Chemother., 53, 4949-4952.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
BAL0030543 a dihydrophthalazine inhibitor with antibacterial activity, overview Staphylococcus aureus
BAL0030543 a dihydrophthalazine inhibitor with antibacterial activity, overview Streptococcus mitis
BAL0030543 a dihydrophthalazine inhibitor with antibacterial activity, overview Streptococcus pneumoniae
BAL0030544 a dihydrophthalazine inhibitor with antibacterial activity, overview Staphylococcus aureus
BAL0030544 a dihydrophthalazine inhibitor with antibacterial activity, overview Streptococcus mitis
BAL0030544 a dihydrophthalazine inhibitor with antibacterial activity, overview Streptococcus pneumoniae
BAL0030545 a dihydrophthalazine inhibitor with antibacterial activity, overview Staphylococcus aureus
BAL0030545 a dihydrophthalazine inhibitor with antibacterial activity, overview Streptococcus mitis
BAL0030545 a dihydrophthalazine inhibitor with antibacterial activity, overview Streptococcus pneumoniae
trimethoprim
-
Staphylococcus aureus
trimethoprim
-
Streptococcus mitis
trimethoprim
-
Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
methicillin-sensitive and -resistant strains
-
Streptococcus mitis
-
methicillin-sensitive and -resistant strains
-
Streptococcus pneumoniae
-
methicillin-sensitive and -resistant strains
-

Synonyms

Synonyms Comment Organism
DHFR
-
Staphylococcus aureus
DHFR
-
Streptococcus pneumoniae
DHFR
-
Streptococcus mitis

General Information

General Information Comment Organism
physiological function dihydrofolate reductase is an enzyme with a pivotal role in the synthesis of intracellular tetrahydrofolic acid, which is essential in the synthesis of purines, some amino acids, and thymidine. DHFR is the sole source of tetrahydrofolic acid Staphylococcus aureus
physiological function dihydrofolate reductase is an enzyme with a pivotal role in the synthesis of intracellular tetrahydrofolic acid, which is essential in the synthesis of purines, some amino acids, and thymidine. DHFR is the sole source of tetrahydrofolic acid Streptococcus pneumoniae
physiological function dihydrofolate reductase is an enzyme with a pivotal role in the synthesis of intracellular tetrahydrofolic acid, which is essential in the synthesis of purines, some amino acids, and thymidine. DHFR is the sole source of tetrahydrofolic acid Streptococcus mitis