Literature summary for 1.5.1.3 extracted from

Mishra, P.J.; Humeniuk, R.; Mishra, P.J.; Longo-Sorbello, G.S.; Banerjee, D.; Bertino, J.R.
A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance (2007), Proc. Natl. Acad. Sci. USA, 104, 13513-13518.

Search for more literature for 1.5.1.3

Application

Application	Comment	Organism
medicine	the naturally occurring single nucleotide polymorhism C829T, near the miR-24 binding site in the 3' UTR of human dihydrofolate reductase leads to a decrease in microRNA binding, which in turn leads to overexpression of its target and results in resistance to methotrexate	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C829T	naturally occurring single nucleotide polymorhism , near the miR-24 binding site in the 3' UTR of human dihydrofolate reductase leads to a decrease in microRNA binding, which in turn leads to overexpression of its target and results in resistance to methotrexate	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
methotrexate	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)