Literature summary for 1.5.1.3 extracted from

Guijon, F.B.; Greulich-Bode, K.; Paraskevas, M.; Baker, P.; Mai, S.
Premalignant cervical lesions are characterized by dihydrofolate reductase gene amplification and c-Myc overexpression: possible biomarkers (2007), J. Low. Genit. Tract. Dis., 11, 265-272.

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Application

Application	Comment	Organism
medicine	c-Myc oncoprotein protein level is elevated in cervical intraepithelial neoplasia 1, cervical intraepithelial neoplasia 2, cervical intraepithelial neoplasia 3 biopsies. Concomitantly, dihydrofolate reductase gene amplification is detected. The degrees of dihydrofolate reductase gene amplification and of c-Myc protein levels are a measure of the progressive degree of the lesion	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cervical epithelium	cervical tissue biopsies, including cervical intraepithelial neoplasia 1, cervical intraepithelial neoplasia 2, cervical intraepithelial neoplasia 3	Homo sapiens	-

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Release 2023.1 (January 2023)