Literature summary for 1.5.1.3 extracted from

Argyrou, A.; Vetting, M.W.; Aladegbami, B.; Blanchard, J.S.
Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid (2006), Nat. Struct. Mol. Biol., 13, 408-413.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with inhibitor isoniazid, acyclic 4R isonicotinoyl-NADP adduct binds to and inhibits enzyme	Mycobacterium tuberculosis

Inhibitors

Inhibitors	Comment	Organism	Structure
isoniazid	acyclic 4R isonicotinoyl-NADP adduct binds to enzyme	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WNX1	-	-
Mycobacterium tuberculosis H37Rv	P9WNX1	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000001	-	isoniazid	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)