Literature summary for 1.5.1.3 extracted from

Baker, B.R.
Tissue-specific irreversible inhibitors of dihydrofolic reductase (1969), Acc. Chem. Res., 2, 129-136.

No PubMed abstract available

Search for more literature for 1.5.1.3

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	overview	Mus musculus
additional information	overview	Pigeon
additional information	overview	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	overview	-
Pigeon	-	overview	-
Rattus norvegicus	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+	inhibitor binding mechanism	Mus musculus	a
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+	inhibitor binding mechanism	Rattus norvegicus	a
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+	inhibitor binding mechanism	Pigeon	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
intestine	-	Mus musculus	-
L-1210 cell	-	Mus musculus	-
liver	-	Mus musculus	-
liver	-	Rattus norvegicus	-
liver	-	Pigeon	-
LLC-WRC 256 cell	tumor cell line	Rattus norvegicus	-
spleen	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7,8-dihydrofolate + NADPH	-	Mus musculus	5,6,7,8-tetrahydrofolate + NADP+	-	ir
7,8-dihydrofolate + NADPH	-	Rattus norvegicus	5,6,7,8-tetrahydrofolate + NADP+	-	ir
7,8-dihydrofolate + NADPH	-	Pigeon	5,6,7,8-tetrahydrofolate + NADP+	-	ir

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Mus musculus
NADPH	-	Rattus norvegicus
NADPH	-	Pigeon

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)