Application | Comment | Organism |
---|---|---|
medicine | enzyme is a target of several anti-folate inhibitory drugs to combat bacteria, protozoa and cancer | Gallus gallus |
medicine | enzyme is a target of several anti-folate inhibitory drugs to combat bacteria, protozoa and cancer | Escherichia coli |
medicine | enzyme is a target of several anti-folate inhibitory drugs to combat bacteria, protozoa and cancer | Homo sapiens |
medicine | enzyme is a target of several anti-folate inhibitory drugs to combat bacteria, protozoa and cancer | Sus scrofa |
medicine | enzyme is a target of several anti-folate inhibitory drugs to combat bacteria, protozoa and cancer | Bos taurus |
medicine | enzyme is a target of several anti-folate inhibitory drugs to combat bacteria, protozoa and cancer | Lacticaseibacillus casei |
medicine | enzyme is a target of several anti-folate inhibitory drugs to combat bacteria, protozoa and cancer | Enterococcus faecium |
Crystallization (Comment) | Organism |
---|---|
crystal structure, complex with 2,4-diamino-5,6-dihydro-6,6-dimethyl-5-(4'-methoxyphenyl)-s-triazine | Gallus gallus |
structure of ternary complex with NADPH and methotrexate | Escherichia coli |
structure of ternary complex with NADPH and methotrexate | Lacticaseibacillus casei |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,4-diamino-5,6-dihydro-6,6-dimethyl-5-(4'-methoxyphenyl)-s-triazine | - |
Gallus gallus | |
methotrexate | - |
Bos taurus | |
methotrexate | dihydrofolate antagonist drug | Escherichia coli | |
methotrexate | - |
Gallus gallus | |
methotrexate | dihydrofolate antagonist drug | Homo sapiens | |
methotrexate | - |
Lacticaseibacillus casei | |
methotrexate | - |
Sus scrofa | |
additional information | overview | Bos taurus | |
additional information | overview | Enterococcus faecium | |
additional information | overview | Escherichia coli | |
additional information | overview | Gallus gallus | |
additional information | overview | Lacticaseibacillus casei | |
additional information | overview | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
overview | - |
Enterococcus faecium | - |
overview | - |
Escherichia coli | - |
- |
- |
Gallus gallus | - |
overview | - |
Homo sapiens | - |
methotrexate-resistant WIL-2 lymphoblastoid cells | - |
Lacticaseibacillus casei | - |
- |
- |
Sus scrofa | - |
overview | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ | inhibitor binding mechanism | Gallus gallus | |
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ | inhibitor binding mechanism | Escherichia coli | |
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ | inhibitor binding mechanism | Homo sapiens | |
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ | inhibitor binding mechanism | Sus scrofa | |
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ | inhibitor binding mechanism | Bos taurus | |
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ | inhibitor binding mechanism | Lacticaseibacillus casei | |
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ | inhibitor binding mechanism | Enterococcus faecium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH | - |
Gallus gallus | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH | - |
Escherichia coli | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH | - |
Homo sapiens | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH | - |
Sus scrofa | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH | - |
Bos taurus | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH | - |
Lacticaseibacillus casei | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH | - |
Enterococcus faecium | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Gallus gallus | |
NADPH | - |
Escherichia coli | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Sus scrofa | |
NADPH | - |
Bos taurus | |
NADPH | - |
Lacticaseibacillus casei | |
NADPH | - |
Enterococcus faecium |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000037 | - |
2,4-diamino-5,6-dihydro-6,6-dimethyl-5-(4'-methoxyphenyl)-s-triazine | - |
Gallus gallus |