Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
OVCAR-3 cell | - |
Homo sapiens | - |
OVCAR-5 cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | oxidized low-density lipoproteins upregulate proline oxidase through nuclear receptor peroxisome proliferator-activated receptor gamma | up |
General Information | Comment | Organism |
---|---|---|
physiological function | treatment with oxidized low-density lipoproteins decreases the cell number per field and causes the cells to round up. Knock-down of proline oxidase via small interfering RNA further reduces viability of cancer cells treated with oxidized low-density lipoproteins, decreases oxidized low-density lipoproteins-associated reactive oxygen species generation, decreases autophagy measured via beclin-1 protein level and light-chain 3 protein-I into LC3-II conversion. Single proline oxidase overexpression is sufficient to activate autophagy. It leads to autophagosomes accumulation and increases conversion of LC3-I into LC3-II.Beclin-1 gene expression is directly dependent on proline oxidase catalytic activity, namely the generation of prloine-oxidase-dependent superoxide | Homo sapiens |