Literature summary for 1.5.1.2 extracted from

Liu, Y.; Borchert, G.L.; Surazynski, A.; Hu, C.A.; Phang, J.M.
Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling (2006), Oncogene, 25, 5640-5647.

Search for more literature for 1.5.1.2

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrial inner membrane	-	Homo sapiens	5743	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-proline + NAD(P)+	Homo sapiens	-	1-pyrroline-5-carboxylate + NAD(P)H + H+	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
DLD-1 cell	colorectal cancer cell, DLD-1 Tet-Off POX cells are generated for controlled expression of proline oxidase	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-proline + NAD(P)+	-	Homo sapiens	1-pyrroline-5-carboxylate + NAD(P)H + H+	-	r

Synonyms

Synonyms	Comment	Organism
POX	-	Homo sapiens
proline oxidase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD(P)H	-	Homo sapiens

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Release 2023.1 (January 2023)