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Literature summary for 1.5.1.2 extracted from
- Pyrroline-5-carboxylate reductase of Neurospora crassa: partial purification and some properties (1959), J. Biol. Chem., 234, 335-338.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Neurospora crassa | |
| 0.45 | - |
1-pyrroline-5-carboxylate | with NADPH | Neurospora crassa |  |
| 0.53 | - |
1-pyrroline-5-carboxylate | with NADH | Neurospora crassa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Neurospora crassa | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyrroline-5-carboxylate + NAD(P)H + H+ | Escherichia coli | - |
L-proline + NAD(P)+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Neurospora crassa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Neurospora crassa |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
various growth stages | Neurospora crassa |
| 615 | - |
- |
Neurospora crassa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-pyrroline-5-carboxylate + NAD(P)H + H+ | - |
Escherichia coli | L-proline + NAD(P)+ | - |
? | |
| 1-pyrroline-5-carboxylate + NAD(P)H + H+ | - |
Neurospora crassa | L-proline + NAD(P)+ | - |
? | |
| 1-pyrroline-5-carboxylate + NADH + H+ | - |
Neurospora crassa | L-proline + NAD+ | - |
r | |
| 1-pyrroline-5-carboxylate + NADPH + H+ | - |
Neurospora crassa | L-proline + NADP+ | - |
r | |
| pyrroline-5-carboxylate + NAD(P)H + H+ | - |
Escherichia coli | L-proline + NAD(P)+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
cofactor NADH | Neurospora crassa |
| 7 | - |
cofactor NADPH | Neurospora crassa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | preferentially | Escherichia coli | |
| NADH | preferentially | Neurospora crassa | |
| NADPH | - |
Escherichia coli | |
| NADPH | - |
Neurospora crassa | |
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Release 2023.1 (January 2023)
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