Literature summary for 1.5.1.2 extracted from

Valle, D.; Downing, S.J.; Phang, J.M.
Proline inhibition of pyrroline-5-carboxylate reductase: differences in enzymes obtained from animal and tissue culture sources (1973), Biochem. Biophys. Res. Commun., 54, 1418-1424.

Search for more literature for 1.5.1.2

Inhibitors

Inhibitors	Comment	Organism	Structure
proline	-	Cricetulus griseus
proline	competitive inhibition	Homo sapiens
proline	-	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.44	-	1-pyrroline-5-carboxylate	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Cricetulus griseus	-	Chinese hamster, CHO and CHL cells	-
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Homo sapiens	-
hepatoma cell	-	Rattus norvegicus	-
lung	-	Cricetulus griseus	-
ovary	-	Cricetulus griseus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Cricetulus griseus
additional information	-	-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-pyrroline-5-carboxylate + NADH + H+	-	Homo sapiens	L-proline + NAD+	-	r

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	-	Cricetulus griseus
additional information	-	additional information	-	Homo sapiens
additional information	-	additional information	-	Rattus norvegicus

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Release 2023.1 (January 2023)