Protein Variants | Comment | Organism |
---|---|---|
additional information | primary fibroblasts from embryo of knock-out mice, spontaneous immortalization, the mutant cells require methionine and glycine for growth, glycine auxotrophy, replacement of mehtionine by homocysteine results in much lower enzyme activity, metabolism overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mus musculus | |
phosphate | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + NAD+ | Mus musculus | - |
5,10-methenyltetrahydrofolate + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
bifunctional enzyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | enzyme is expressed during embryogenesis and in all immortilized cells | Mus musculus | - |
fibroblast | primary embryonic | Mus musculus | - |
additional information | cell growth studies, wild-type and mutant cell lines, overview | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + NAD+ | - |
Mus musculus | 5,10-methenyltetrahydrofolate + NADH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methylenetetrahydrofolate dehydrogenase-cyclohydrolase | - |
Mus musculus |
methyleneTHF dehydrogenase | - |
Mus musculus |
NMDMC | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Mus musculus |